The Developmental Biologist works within mammalian species teams to design and conduct experiments that will inform genetic engineering for de-extinction projects. Leveraging their expertise in genetics and developmental biology, they will work closely with bioinformaticians to identify phenotype-relevant genetic pathways and variants and test the effect of those variants in embryonic, organoid, and cellular models.**This position is based on-site in Dallas, TX. Relocation assistance is available**Duties and Responsibilities:<ul><li>Maintain expertise and familiarity with genetics and development literature </li><li>Microdissect defined substructures from stem cell niches that give rise to mineralized and cornified hard-tissue and soft-tissue epithelial-mesenchymal appendages</li><li>Stage, sample, and manipulate fetal and embryonic tissues and structures</li><li>Design, develop, and implement novel experiments, techniques, procedures, protocols, and systems in line with research program objectives for non-model animals</li><li>Build RNase-safe, low-input workflows from collection through library QC for multiomic data including bulk, single-cell, and spatial gene expression and chromatin conformation, state, and accessibility assays</li><li>Work closely with the bioinformatics team to identify genetic variants of interest</li><li>Process, image, and analyze fetuses of various stages using techniques such as fluorescent microscopy, whole mount skeletal staining and morphometrics</li><li>Contribute to, and be responsible for, documentation, reports, presentations and publications associated with work </li></ul>Skills and Abilities:<ul><li>Hands-on wet lab experience with mammalian fetal development, sampling and manipulation, such as electroporation or embryonic tissue transplantation, OR relevant experience in other fetal system</li><li>Strong working knowledge of gene regulatory networks in fetal development</li><li>Demonstrated success in preparing DNA and RNA from low-input or challenging tissues for multiomic assays (e.g., scRNA-seq, scATAC-seq, CUT&amp;RUN/CUT&amp;Tag/ChIP-seq)</li><li>Strong working knowledge of research methodology and study design; hypothesis testing; qualitative and quantitative data interpretation and application</li><li>Exceptional verbal and written communication skills</li><li>Demonstrated ability to take the initiative to move projects forward, make independent judgments, maintain accurate lab data, clearly understand and respond to experimental results, while communicating effectively</li><li>Ability to work independently and collaboratively, as required, in a fast-paced, matrixed, team environment consisting of internal and external team members</li><li>Analytical and creative thinker with excellent problem-solving skills and the ability to prioritize own work and adapt to changing team priorities</li><li>Excellent planning, organization and time management skills</li><li>Very high level of comfort with productivity and communication software platforms (MS Office, GSuite, Slack, digital notebooks, project management systems, etc.)</li></ul>Qualifications:<ul><li>DVM/PHD in developmental biology, biological sciences, veterinary medicine, bioengineering, molecular biology, genetics, or any science related field is required</li><li>2+ years of wet lab research experience in developmental biology strongly preferred</li><li>2+ years of experience working with bioinformaticians or computational biologists on generating multiomic data sets strongly preferred </li></ul><div>What Colossal Offers Full-Time Employees:<ul><li style="font-weight:400;">Medical, dental, and vision coverage</li><li style="font-weight:400;">Excellent paid time off and company holidays so you can rest and recharge </li><li style="font-weight:400;">Flexible spending accounts (FSA)</li><li style="font-weight:400;">Company matched 401k retirement plan</li><li style="font-weight:400;">Paid parental leave at 100% salary for up to 12 weeks</li><li style="font-weight:400;">Education reimbursement </li><li style="font-weight:400;">An opportunity to help us return the Earth to a healthier state</li></ul>The team at Colossal is committed, colorful, passionate, intelligent, collaborative, creative, experienced, scientific and world-class. That sounds like a lot to fit into one building. That’s why we are spread out in several locations that include laboratories, test facilities, academic institutions, libraries and offices. Through it all, however, we maintain a culture of positivity, hope, happiness and belief that we’re doing something big. Something Colossal.Colossal is proud to be an equal employment opportunity workplace. We welcome people from all backgrounds as well as celebrate and support diversity. We are committed to providing an inclusive environment of mutual respect that is free from discrimination and harassment so everyone can thrive. <a href="https://www.eeoc.gov/after-june-27-2023-know-your-rights-workplace-discrimination-illegal">EEO is the Law </a>Search Firm Representatives: Colossal does not accept unsolicited assistance from search firms. No fees will be paid for a hired candidate where no pre-existing agreement is in place. We handle most recruitment in-house. Colossal is proud to be named a Best Place to Work by BuiltIn for 3 years in a row across multiple categories in 2023, 2024, and 2025:<ul><li>#1 on the 50 Best Startups to Work For in Dallas in 2023!</li><li>100 Best Midsize Places to Work in Dallas in 2024 &amp; 2025</li><li>100 Best Places to Work in Dallas, TX (All Size Employers) in 2024 &amp; 2025</li></ul> <a href="https://builtin.com/awards/dallas/2025/best-midsize-places-to-work">Built In 2025 Award Lists</a><a href="https://www.greatplacetowork.com/certified-company/7049203">Great Place to Work Certification Page</a><a href="https://mostlovedworkplace.com/companies/colossal-biosciences/">Most Loved Workplace Certification Page</a> - Proud to be certified as a most loved workplace including: most loved CEO, most loved workplaces for LGBTQ+, most loved workplaces for women, and most loved workplaces for young professionals.<a href="https://www.newsweek.com/rankings/most-loved-workplaces-2024?utm_campaign=dr_2024_oct_webinar_final&amp;utm_medium=email&amp;_hsenc=p2ANqtz-8dglCEGpx_mr-HYudRKFhj4L6PhGDkf92pJJMpxovuNaX_Y7rdOFsgX6dEGZnNK9O_RP1gd54PPR7yib9CZjvG7FT4IA&amp;_hsmi=328042950&amp;utm_content=see_list&amp;utm_source=newlsetter">Newsweek's Most Loved Workplaces 2024 Award List</a> - Excited to be amongst the winners of Newsweek's 2024 Most Loved Workplaces! <img style="max-width:100%;" src="https://employers.builtin.com/wp-content/uploads/2023/09/2024BPTW_GeneralBadgeYear_AllWhite-1-281x300.png">   <img style="max-width:100%;" src="https://www.greatplacetowork.com/images/profiles/7049203/companyBadge.png?20240207">     <img style="max-width:100%;" src="https://pbs.twimg.com/media/FvJDPn0aEAAwgAH?format=jpg&amp;name=small">    <img style="max-width:100%;" src="https://colossal.com/wp-content/uploads/time-100.png"> <img style="max-width:100%;" src="https://imageio.forbes.com/dam/imageserve/65e730dcd08766cc9dbcdb47/x.jpg?format=jpg&amp;height=183&amp;width=255&amp;fit=bounds"> </div>

The science of genetics. The business of discovery.
Colossal is a breakthrough bioscience and genetic engineering company that builds radical new technologies to advance the field of genomics. Colossal creates disruptive technologies for extinct species restoration, critically endangered species protection and the repopulation of critical ecosystems that support the continuation of life on Earth. The company is the first to apply CRISPR technology for the purposes of species de-extinction, beginning with the woolly mammoth. Colossal is accepting humanity&rsquo;s duty to restore Earth to a healthier state, while also solving for the future economies and biological necessities of the human condition through cutting-edge science and technologies.

Scientist, Developmental Biology

The Developmental Biologist works within mammalian species teams to design and conduct experiments that will inform genetic engineering for de-extinction projects. Leveraging their expertise in genetics and developmental biology, they will work closely with bioinformaticians to identify phenotype-relevant genetic pathways and variants and test the effect of those variants in embryonic, organoid, and cellular models.**This position is based on-site in Dallas, TX. Relocation assistance is available**Duties and Responsibilities:<ul><li>Maintain expertise and familiarity with genetics and development literature&nbsp;</li><li>Microdissect defined substructures from stem cell niches that give rise to mineralized and cornified hard-tissue and soft-tissue epithelial-mesenchymal appendages</li><li>Stage, sample, and manipulate fetal and embryonic tissues and structures</li><li>Design, develop, and implement novel experiments, techniques, procedures, protocols, and systems in line with research program objectives for non-model animals</li><li>Build RNase-safe, low-input workflows from collection through library QC for multiomic data including bulk, single-cell, and spatial gene expression and chromatin conformation, state, and accessibility assays</li><li>Work closely with the bioinformatics team to identify genetic variants of interest</li><li>Process, image, and analyze fetuses of various stages using techniques such as fluorescent microscopy, whole mount skeletal staining and morphometrics</li><li>Contribute to, and be responsible for, documentation, reports, presentations and publications associated with work&nbsp;</li></ul>Skills and Abilities:<ul><li>Hands-on wet lab experience with mammalian fetal development, sampling and manipulation, such as electroporation or embryonic tissue transplantation, OR relevant experience in other fetal system</li><li>Strong working knowledge of gene regulatory networks in fetal development</li><li>Demonstrated success in preparing DNA and RNA from low-input or challenging tissues for multiomic assays (e.g., scRNA-seq, scATAC-seq, CUT&amp;RUN/CUT&amp;Tag/ChIP-seq)</li><li>Strong working knowledge of research methodology and study design; hypothesis testing; qualitative and quantitative data interpretation and application</li><li>Exceptional verbal and written communication skills</li><li>Demonstrated ability to take the initiative to move projects forward, make independent judgments, maintain accurate lab data, clearly understand and respond to experimental results, while communicating effectively</li><li>Ability to work independently and collaboratively, as required, in a fast-paced, matrixed, team environment consisting of internal and external team members</li><li>Analytical and creative thinker with excellent problem-solving skills and the ability to prioritize own work and adapt to changing team priorities</li><li>Excellent planning, organization and time management skills</li><li>Very high level of comfort with productivity and communication software platforms (MS Office, GSuite, Slack, digital notebooks, project management systems, etc.)</li></ul>Qualifications:<ul><li>DVM/PHD in developmental biology, biological sciences, veterinary medicine, bioengineering, molecular biology, genetics, or any science related field is required</li><li>2+ years of wet lab research experience in developmental biology strongly preferred</li><li>2+ years of experience working with bioinformaticians or computational biologists on generating multiomic data sets strongly preferred&nbsp;</li></ul><div>What Colossal Offers Full-Time Employees:<ul><li>Medical, dental, and vision coverage</li><li>Excellent paid time off and company holidays so you can rest and recharge&nbsp;</li><li>Flexible spending accounts (FSA)</li><li>Company matched 401k retirement plan</li><li>Paid parental leave at 100% salary for up to 12 weeks</li><li>Education reimbursement&nbsp;</li><li>An opportunity to help us return the Earth to a healthier state</li></ul>The team at Colossal is committed, colorful, passionate, intelligent, collaborative, creative, experienced, scientific and world-class. That sounds like a lot to fit into one building. That’s why we are spread out in several locations that include laboratories, test facilities, academic institutions, libraries and offices.&nbsp;Through it all, however, we maintain a culture of positivity, hope, happiness and belief that we’re doing something big. Something Colossal.Colossal is proud to be an equal employment opportunity workplace. We welcome people from all backgrounds as well as celebrate and support diversity. We are committed to providing an inclusive environment of mutual respect that is free from discrimination and harassment so everyone can thrive.&nbsp;<a href="https://www.eeoc.gov/after-june-27-2023-know-your-rights-workplace-discrimination-illegal">EEO is the Law&nbsp;</a>Search Firm Representatives: Colossal does not accept unsolicited assistance from search firms. No fees will be paid for a hired candidate where no pre-existing agreement is in place. We handle most recruitment in-house.&nbsp;Colossal is proud to be named a Best Place to Work by BuiltIn for 3 years in a row across multiple categories in 2023, 2024, and 2025:<ul><li>#1 on the 50 Best Startups to Work For in Dallas in 2023!</li><li>100 Best Midsize Places to Work in Dallas in 2024 &amp; 2025</li><li>100 Best Places to Work in Dallas, TX (All Size Employers) in 2024 &amp; 2025</li></ul> <a href="https://builtin.com/awards/dallas/2025/best-midsize-places-to-work">Built In 2025 Award Lists</a><a href="https://www.greatplacetowork.com/certified-company/7049203">Great Place to Work Certification Page</a><a href="https://mostlovedworkplace.com/companies/colossal-biosciences/">Most Loved Workplace Certification Page</a> - Proud to be certified as a most loved workplace including: most loved CEO, most loved workplaces for LGBTQ+, most loved workplaces for women, and most loved workplaces for young professionals.<a href="https://www.newsweek.com/rankings/most-loved-workplaces-2024?utm_campaign=dr_2024_oct_webinar_final&amp;utm_medium=email&amp;_hsenc=p2ANqtz-8dglCEGpx_mr-HYudRKFhj4L6PhGDkf92pJJMpxovuNaX_Y7rdOFsgX6dEGZnNK9O_RP1gd54PPR7yib9CZjvG7FT4IA&amp;_hsmi=328042950&amp;utm_content=see_list&amp;utm_source=newlsetter">Newsweek's Most Loved Workplaces 2024 Award List</a> - Excited to be amongst the winners of Newsweek's 2024 Most Loved Workplaces!&nbsp;<img src="https://employers.builtin.com/wp-content/uploads/2023/09/2024BPTW_GeneralBadgeYear_AllWhite-1-281x300.png">&nbsp; &nbsp;<img src="https://www.greatplacetowork.com/images/profiles/7049203/companyBadge.png?20240207">&nbsp; &nbsp; &nbsp;<img src="https://pbs.twimg.com/media/FvJDPn0aEAAwgAH?format=jpg&amp;name=small"> &nbsp; &nbsp;<img src="https://colossal.com/wp-content/uploads/time-100.png"> <img src="https://imageio.forbes.com/dam/imageserve/65e730dcd08766cc9dbcdb47/x.jpg?format=jpg&amp;height=183&amp;width=255&amp;fit=bounds">&nbsp;</div>

Scientist, Developmental Biology

About the Job

About the Company

Colossal Biosciences

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