The Scientist will develop novel media formulations to culture primordial germ cells (PGCs) from non-model organisms, conduct functional assays, and in vitro characterization of PGCs. The candidate will be part of an innovative synthetic biology platform that will develop and optimize a cell culture media platform for the production and expansion of PGCs with downstream assays to assess germline functionality from non-model avian species. This role supports Colossal’s avian program, establishing PGC lines to support conservation breeding and genetic rescue. This position is based out of Dallas, TX, and may require some international travel. Relocation assistance is provided.Duties and Responsibilities:<ul><li>Innovate and execute experiments to culture primordial germ cells (PGCs) from non-model avian organisms</li><li>Using a dissection microscope, collect blood and tissue from avian embryos for use in cell line derivations.</li><li>Test novel PGC culture conditions, sort, screen, expand PGCs according to latest protocols and newly developed approaches, particularly as it relates to the germ cell lineage</li><li>Interpret scRNA-seq and rt-qPCR datasets and apply this data to develop novel media formulations tailored to specific avian species</li><li>Work with the Avian Embryology team to develop protocols for injection of PGCs into early-stage embryos</li><li>Own and deliver PGC derivation and culture milestones</li><li>Attend lab meetings, prepare reports and presentations on the progress of projects</li><li>Maintain detailed, accurate laboratory records and protocols</li></ul>Required Skills and Abilities:<ul><li>Expert knowledge of cell culture, primary cell derivation, and propagation methodologies, preferably with PGCs.</li><li>Previous experience optimizing growth media conditions for cell culture</li><li>Experience staging and manipulating avian embryos including injection into early-stage embryos</li><li>Experience in molecular biology (RNA extraction, qPCR) </li><li>Experience with rt-qPCR and flow cytometry</li><li>Track record of working closely with computational collaborators to interpret scRNA-seq data</li><li>Strong written and oral communication skills, as well as creative problem-solving skills</li><li>Enjoys the fast-paced startup environment and teamwork</li><li>Exceptional organizational skills and attention to detail</li><li>Strong emotional intelligence and passion for building relationships across all levels</li><li>Strong analytical and problem-solving skills</li><li>Ability to function well in a growth-oriented, nimble environment</li></ul>Preferred Experience:<ul><li>Experience deriving or culturing PGCs from avian species</li><li>Previous work optimizing media for challenging cell types</li></ul>Education and Experience:<ul><li>PhD in biological sciences, stem cell or germ cell biology, or related field. </li><li>Postdoctoral or industry experience in stem cell or germ cell biology.</li></ul><div>What Colossal Offers Full-Time Employees:<ul><li style="font-weight:400;">Medical, dental, and vision coverage</li><li style="font-weight:400;">Excellent paid time off and company holidays so you can rest and recharge </li><li style="font-weight:400;">Flexible spending accounts (FSA)</li><li style="font-weight:400;">Company matched 401k retirement plan</li><li style="font-weight:400;">Paid parental leave at 100% salary for up to 12 weeks</li><li style="font-weight:400;">Education reimbursement </li><li style="font-weight:400;">An opportunity to help us return the Earth to a healthier state</li></ul>The team at Colossal is committed, colorful, passionate, intelligent, collaborative, creative, experienced, scientific and world-class. That sounds like a lot to fit into one building. That’s why we are spread out in several locations that include laboratories, test facilities, academic institutions, libraries and offices. Through it all, however, we maintain a culture of positivity, hope, happiness and belief that we’re doing something big. Something Colossal.Colossal is proud to be an equal employment opportunity workplace. We welcome people from all backgrounds as well as celebrate and support diversity. We are committed to providing an inclusive environment of mutual respect that is free from discrimination and harassment so everyone can thrive. <a href="https://www.eeoc.gov/after-june-27-2023-know-your-rights-workplace-discrimination-illegal">EEO is the Law </a>Search Firm Representatives: Colossal does not accept unsolicited assistance from search firms. No fees will be paid for a hired candidate where no pre-existing agreement is in place. We handle most recruitment in-house. Colossal is on LinkedIn's 2026 Top Startups in Dallas List! See the list <a href="https://www.linkedin.com/pulse/linkedin-top-startups-2026-10-companies-rise-dallas-linkedin-news-hmeif/?trackingId=5LNMrCECIKfydCVNT3xTAA%3D%3D">here.</a>Colossal is on Fortune's 2026 List for Best Workplaces in BioPharma. See the list <a href="https://www.greatplacetowork.com/best-workplaces/biopharma/2026?category=small-and-medium">here</a>. Colossal is proud to be named a Best Place to Work by BuiltIn for 4 years in a row across multiple categories in 2023, 2024, 2025, and 2026:<ul><li>#1 on the 50 Best Startups to Work For in Dallas in 2023!</li><li>100 Best Midsize Places to Work in Dallas in 2024 &amp; 2025</li><li>100 Best Places to Work in Dallas, TX (All Size Employers) in 2024, 2025, and 2026.</li></ul> <a href="https://builtin.com/awards/dallas/2026/best-places-to-work">Built In 2026 Award Lists</a><a href="https://www.greatplacetowork.com/certified-company/7049203">Great Place to Work Certification Page</a><a href="https://mostlovedworkplace.com/companies/colossal-biosciences/">Most Loved Workplace Certification Page</a> - Proud to be certified as a most loved workplace including: most loved CEO, most loved workplaces for LGBTQ+, most loved workplaces for women, and most loved workplaces for young professionals.<a href="https://www.newsweek.com/rankings/most-loved-workplaces-2024?utm_campaign=dr_2024_oct_webinar_final&amp;utm_medium=email&amp;_hsenc=p2ANqtz-8dglCEGpx_mr-HYudRKFhj4L6PhGDkf92pJJMpxovuNaX_Y7rdOFsgX6dEGZnNK9O_RP1gd54PPR7yib9CZjvG7FT4IA&amp;_hsmi=328042950&amp;utm_content=see_list&amp;utm_source=newlsetter">Newsweek's Most Loved Workplaces 2024 Award List</a> - Excited to be amongst the winners of Newsweek's 2024 Most Loved Workplaces! <img style="max-width:100%;" src="https://employers.builtin.com/wp-content/uploads/2023/09/2024BPTW_GeneralBadgeYear_AllWhite-1-281x300.png">   <img style="max-width:100%;" src="https://www.greatplacetowork.com/images/profiles/7049203/companyBadge.png?20240207">     <img style="max-width:100%;" src="https://pbs.twimg.com/media/FvJDPn0aEAAwgAH?format=jpg&amp;name=small">     <img style="max-width:100%;" src="https://imageio.forbes.com/dam/imageserve/65e730dcd08766cc9dbcdb47/x.jpg?format=jpg&amp;height=183&amp;width=255&amp;fit=bounds"> <img style="max-width:100%;" src="https://drive.google.com/file/d/1OfyDuXFTNF7LBhvIuV9E605m7rOrdizP/view?usp=drive_link"> </div>

The science of genetics. The business of discovery.
Colossal is a breakthrough bioscience and genetic engineering company that builds radical new technologies to advance the field of genomics. Colossal creates disruptive technologies for extinct species restoration, critically endangered species protection and the repopulation of critical ecosystems that support the continuation of life on Earth. The company is the first to apply CRISPR technology for the purposes of species de-extinction, beginning with the woolly mammoth. Colossal is accepting humanity&rsquo;s duty to restore Earth to a healthier state, while also solving for the future economies and biological necessities of the human condition through cutting-edge science and technologies.

Scientist, Avian Cell Engineering

The Scientist will develop novel media formulations to culture primordial germ cells (PGCs) from non-model organisms, conduct functional assays, and in vitro characterization of PGCs. The candidate will be part of an innovative synthetic biology platform that will develop and optimize a cell culture media platform for the production and expansion of PGCs with downstream assays to assess germline functionality from non-model avian species. This role supports Colossal’s avian program, establishing PGC lines to support conservation breeding and genetic rescue. This position is based out of Dallas, TX, and may require some international travel. Relocation assistance is provided.Duties and Responsibilities:<ul><li>Innovate and execute experiments to culture primordial germ cells (PGCs) from non-model avian organisms</li><li>Using a dissection microscope, collect blood and tissue from avian embryos for use in cell line derivations.</li><li>Test novel PGC culture conditions, sort, screen, expand PGCs according to latest protocols and newly developed approaches, particularly as it relates to the germ cell lineage</li><li>Interpret scRNA-seq and rt-qPCR datasets and apply this data to develop novel media formulations tailored to specific avian species</li><li>Work with the Avian Embryology team to develop protocols for injection of PGCs into early-stage embryos</li><li>Own and deliver PGC derivation and culture milestones</li><li>Attend lab meetings, prepare reports and presentations on the progress of projects</li><li>Maintain detailed, accurate laboratory records and protocols</li></ul>Required Skills and Abilities:<ul><li>Expert knowledge of cell culture, primary cell derivation, and propagation methodologies, preferably with PGCs.</li><li>Previous experience optimizing growth media conditions for cell culture</li><li>Experience staging and manipulating avian embryos including injection into early-stage embryos</li><li>Experience in molecular biology (RNA extraction, qPCR) </li><li>Experience with rt-qPCR and flow cytometry</li><li>Track record of working closely with computational collaborators to interpret scRNA-seq data</li><li>Strong written and oral communication skills, as well as creative problem-solving skills</li><li>Enjoys the fast-paced startup environment and teamwork</li><li>Exceptional organizational skills and attention to detail</li><li>Strong emotional intelligence and passion for building relationships across all levels</li><li>Strong analytical and problem-solving skills</li><li>Ability to function well in a growth-oriented, nimble environment</li></ul>Preferred Experience:<ul><li>Experience deriving or culturing PGCs from avian species</li><li>Previous work optimizing media for challenging cell types</li></ul>Education and Experience:<ul><li>PhD in biological sciences, stem cell or germ cell biology, or related field. </li><li>Postdoctoral or industry experience in stem cell or germ cell biology.</li></ul><div>What Colossal Offers Full-Time Employees:<ul><li>Medical, dental, and vision coverage</li><li>Excellent paid time off and company holidays so you can rest and recharge </li><li>Flexible spending accounts (FSA)</li><li>Company matched 401k retirement plan</li><li>Paid parental leave at 100% salary for up to 12 weeks</li><li>Education reimbursement </li><li>An opportunity to help us return the Earth to a healthier state</li></ul>The team at Colossal is committed, colorful, passionate, intelligent, collaborative, creative, experienced, scientific and world-class. That sounds like a lot to fit into one building. That’s why we are spread out in several locations that include laboratories, test facilities, academic institutions, libraries and offices. Through it all, however, we maintain a culture of positivity, hope, happiness and belief that we’re doing something big. Something Colossal.Colossal is proud to be an equal employment opportunity workplace. We welcome people from all backgrounds as well as celebrate and support diversity. We are committed to providing an inclusive environment of mutual respect that is free from discrimination and harassment so everyone can thrive. <a href="https://www.eeoc.gov/after-june-27-2023-know-your-rights-workplace-discrimination-illegal">EEO is the Law </a>Search Firm Representatives: Colossal does not accept unsolicited assistance from search firms. No fees will be paid for a hired candidate where no pre-existing agreement is in place. We handle most recruitment in-house. Colossal is on LinkedIn's 2026 Top Startups in Dallas List! See the list <a href="https://www.linkedin.com/pulse/linkedin-top-startups-2026-10-companies-rise-dallas-linkedin-news-hmeif/?trackingId=5LNMrCECIKfydCVNT3xTAA%3D%3D">here.</a>Colossal is on Fortune's 2026 List for Best Workplaces in BioPharma. See the list <a href="https://www.greatplacetowork.com/best-workplaces/biopharma/2026?category=small-and-medium">here</a>. Colossal is proud to be named a Best Place to Work by BuiltIn for 4 years in a row across multiple categories in 2023, 2024, 2025, and 2026:<ul><li>#1 on the 50 Best Startups to Work For in Dallas in 2023!</li><li>100 Best Midsize Places to Work in Dallas in 2024 &amp; 2025</li><li>100 Best Places to Work in Dallas, TX (All Size Employers) in 2024, 2025, and 2026.</li></ul> <a href="https://builtin.com/awards/dallas/2026/best-places-to-work">Built In 2026 Award Lists</a><a href="https://www.greatplacetowork.com/certified-company/7049203">Great Place to Work Certification Page</a><a href="https://mostlovedworkplace.com/companies/colossal-biosciences/">Most Loved Workplace Certification Page</a> - Proud to be certified as a most loved workplace including: most loved CEO, most loved workplaces for LGBTQ+, most loved workplaces for women, and most loved workplaces for young professionals.<a href="https://www.newsweek.com/rankings/most-loved-workplaces-2024?utm_campaign=dr_2024_oct_webinar_final&amp;utm_medium=email&amp;_hsenc=p2ANqtz-8dglCEGpx_mr-HYudRKFhj4L6PhGDkf92pJJMpxovuNaX_Y7rdOFsgX6dEGZnNK9O_RP1gd54PPR7yib9CZjvG7FT4IA&amp;_hsmi=328042950&amp;utm_content=see_list&amp;utm_source=newlsetter">Newsweek's Most Loved Workplaces 2024 Award List</a> - Excited to be amongst the winners of Newsweek's 2024 Most Loved Workplaces!                </div>

Scientist, Avian Cell Engineering

About the Job

About the Company

Colossal Biosciences

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